Ki Summary

Reaction Details

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Target

Peroxisome proliferator-activated receptor gamma

Ligand

BDBM50049239

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_154537 (CHEMBL760257)

EC50

140±n/a nM

Citation

Willson, TM; Cobb, JE; Cowan, DJ; Wiethe, RW; Correa, ID; Prakash, SR; Beck, KD; Moore, LB; Kliewer, SA; Lehmann, JM The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem39:665-8 (1996) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Peroxisome proliferator-activated receptor gamma

Name:

Peroxisome proliferator-activated receptor gamma

Synonyms:

Nr1c3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG_MOUSE | Pparg

Type:

PROTEIN

Mol. Mass.:

57593.55

Organism:

Mus musculus

Description:

ChEMBL_1453700

Residue:

505

Sequence:

MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQL
LHVIKKTETDMSLHPLLQEIYKDLY

BDBM50049239

n/a

Name

BDBM50049239

Synonyms:

5-[1-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-phenyl}-meth-(Z)-ylidene]-thiazolidine-2,4-dione | CHEMBL128884

Type

Small organic molecule

Emp. Form.

C20H17N3O4S

Mol. Mass.

395.432

SMILES

CN(CCOc1ccc(C=C2SC(O)=NC2=O)cc1)c1nc2ccccc2o1 |w:9.8,c:13|

Structure