| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50049575 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_55116 (CHEMBL884367) |
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| IC50 | 2.5±n/a nM |
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| Citation |  Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii. J Med Chem39:1836-45 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21638.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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| BDBM50049575 |
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| n/a |
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| Name | BDBM50049575 |
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| Synonyms: | 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-phenyl}-ethanone | CHEMBL301795 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N6O |
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| Mol. Mass. | 308.3378 |
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| SMILES | CC(=O)c1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1 |
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| Structure | 
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