| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl-CoA:cholesterol acyltransferase |
|---|
| Ligand | BDBM50005944 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_28665 (CHEMBL649063) |
|---|
| IC50 | 140±n/a nM |
|---|
| Citation |  Kataoka, K; Shiota, T; Takeyasu, T; Minoshima, T; Watanabe, K; Tanaka, H; Mochizuki, T; Taneda, K; Ota, M; Tanabe, H; Yamaguchi, H Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides. J Med Chem39:1262-70 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl-CoA:cholesterol acyltransferase |
|---|
| Name: | Acyl-CoA:cholesterol acyltransferase |
|---|
| Synonyms: | ACAT |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 35405.31 |
|---|
| Organism: | Oryctolagus cuniculus |
|---|
| Description: | n/a |
|---|
| Residue: | 305 |
|---|
| Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
|
|
|
|---|
| BDBM50005944 |
|---|
| n/a |
|---|
| Name | BDBM50005944 |
|---|
| Synonyms: | 2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phenyl)-amide | CHEMBL22373 | CI-976 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H39NO4 |
|---|
| Mol. Mass. | 393.5601 |
|---|
| SMILES | CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC |
|---|
| Structure | 
|
|---|
Search and Browse
