Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50500699 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1549556 (CHEMBL3756219) |
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Ki | 75±n/a nM |
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Citation | Barresi, E; Salerno, S; Marini, AM; Taliani, S; La Motta, C; Simorini, F; Da Settimo, F; Vullo, D; Supuran, CT Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII. Bioorg Med Chem24:921-7 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50500699 |
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n/a |
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Name | BDBM50500699 |
Synonyms: | CHEMBL3753359 |
Type | Small organic molecule |
Emp. Form. | C17H14N4O2S2 |
Mol. Mass. | 370.449 |
SMILES | NS(=O)(=O)c1ccc(Nc2ncc3CSc4ccccc4-c3n2)cc1 |
Structure |
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