Ki Summary

Reaction Details

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Target

cGMP-specific 3',5'-cyclic phosphodiesterase

Ligand

BDBM50050575

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_192642 (CHEMBL798774)

EC50

100±n/a nM

Citation

Dumaître, B; Dodic, N Synthesis and cyclic GMP phosphodiesterase inhibitory activity of a series of 6-phenylpyrazolo[3,4-d]pyrimidones. J Med Chem39:1635-44 (1996) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

cGMP-specific 3',5'-cyclic phosphodiesterase

Name:

cGMP-specific 3',5'-cyclic phosphodiesterase

Synonyms:

PDE5A_RAT | Pde5 | Pde5a | Phosphodiesterase 5A

Type:

PROTEIN

Mol. Mass.:

94547.60

Organism:

Rattus norvegicus

Description:

ChEMBL_155367

Residue:

833

Sequence:

MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKIS
ASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSH
LDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIR
LEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA
QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE
EQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREH
DANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKN
KVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT
LEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDL
NLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLE
TLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILS
GLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTA
CDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFID
AICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKRD

BDBM50050575

n/a

Name

BDBM50050575

Synonyms:

1,3-Dimethyl-6-(5-nitro-2-propoxy-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | CHEMBL290402

Type

Small organic molecule

Emp. Form.

C16H17N5O4

Mol. Mass.

343.3373

SMILES

CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)[N+]([O-])=O

Structure