| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H2 receptor |
|---|
| Ligand | BDBM50050183 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_84898 (CHEMBL694998) |
|---|
| Ki | 31622.78±n/a nM |
|---|
| Citation |  Stark, H; Purand, K; Ligneau, X; Rouleau, A; Arrang, JM; Garbarg, M; Schwartz, JC; Schunack, W Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. J Med Chem39:1157-63 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H2 receptor |
|---|
| Name: | Histamine H2 receptor |
|---|
| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 40567.22 |
|---|
| Organism: | Cavia porcellus (domestic guinea pig) |
|---|
| Description: | For the H2 receptor-binding assays, guinea pig striatum was used. |
|---|
| Residue: | 359 |
|---|
| Sequence: | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
|
|
|
|---|
| BDBM50050183 |
|---|
| n/a |
|---|
| Name | BDBM50050183 |
|---|
| Synonyms: | (4-Iodo-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester | CHEMBL16496 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H16IN3O2 |
|---|
| Mol. Mass. | 385.2002 |
|---|
| SMILES | Ic1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
