| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50051214 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_83437 (CHEMBL859310) |
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| Ki | 50118.72±n/a nM |
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| Citation |  Stark, H; Purand, K; Ligneau, X; Rouleau, A; Arrang, JM; Garbarg, M; Schwartz, JC; Schunack, W Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. J Med Chem39:1157-63 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM50051214 |
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| n/a |
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| Name | BDBM50051214 |
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| Synonyms: | (4-Fluoro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester | CHEMBL263070 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16FN3O2 |
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| Mol. Mass. | 277.2941 |
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| SMILES | Fc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1 |
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| Structure | 
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