| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50501064 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1575430 (CHEMBL3802512) |
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| IC50 | 820±n/a nM |
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| Citation |  Geisman, AN; Valuev-Elliston, VT; Ozerov, AA; Khandazhinskaya, AL; Chizhov, AO; Kochetkov, SN; Pannecouque, C; Naesens, L; Seley-Radtke, KL; Novikov, MS 1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus. Bioorg Med Chem24:2476-85 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50501064 |
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| n/a |
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| Name | BDBM50501064 |
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| Synonyms: | CHEMBL3797710 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N2O4 |
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| Mol. Mass. | 380.437 |
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| SMILES | Cc1cc(C)cc(COCn2c(COCc3ccccc3)cc(=O)[nH]c2=O)c1 |
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| Structure | 
|
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