Reaction Details |
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Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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Ligand | BDBM50501139 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1590145 (CHEMBL3829413) |
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IC50 | 27±n/a nM |
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Citation | Kurasaki, H; Tsuda, K; Shinoyama, M; Takaya, N; Yamaguchi, Y; Kishii, R; Iwase, K; Ando, N; Nomura, M; Kohno, Y LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents. ACS Med Chem Lett7:623-8 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
Synonyms: | LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC |
Type: | Enzyme |
Mol. Mass.: | 33952.00 |
Organism: | Escherichia coli |
Description: | P0A725 |
Residue: | 305 |
Sequence: | MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGI
DELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSAD
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
SAVLA
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BDBM50501139 |
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n/a |
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Name | BDBM50501139 |
Synonyms: | CHEMBL3827962 |
Type | Small organic molecule |
Emp. Form. | C17H13N3O6 |
Mol. Mass. | 355.3016 |
SMILES | ONC(=O)[C@@H]1CN(C(=O)O1)c1ccc(C#CC#CC2CC2)c(c1)[N+]([O-])=O |r| |
Structure |
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