| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50501334 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1628560 (CHEMBL3871145) |
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| Ki | 5000±n/a nM |
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| Citation |  Xiong, Y; Lu, J; Hunter, J; Li, L; Scott, D; Choi, HG; Lim, SM; Manandhar, A; Gondi, S; Sim, T; Westover, KD; Gray, NS Covalent Guanosine Mimetic Inhibitors of G12C KRAS. ACS Med Chem Lett8:61-66 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM50501334 |
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| n/a |
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| Name | BDBM50501334 |
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| Synonyms: | CHEMBL3953729 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20ClN7O10S |
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| Mol. Mass. | 525.878 |
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| SMILES | Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COS(=O)(=O)NC(=O)OCCNC(=O)CCl)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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