Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50052280 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_205723 (CHEMBL807969) |
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IC50 | 0.22±n/a nM |
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Citation | Ladduwahetty, T; Baker, R; Cascieri, MA; Chambers, MS; Haworth, K; Keown, LE; MacIntyre, DE; Metzger, JM; Owen, S; Rycroft, W; Sadowski, S; Seward, EM; Shepheard, SL; Swain, CJ; Tattersall, FD; Watt, AP; Williamson, DW; Hargreaves, RJ N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists. J Med Chem39:2907-14 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50052280 |
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n/a |
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Name | BDBM50052280 |
Synonyms: | (2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-phenyl-1-(4H-[1,2,4]triazol-3-ylmethyl)-piperidine | 3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-phenyl-1-(1H-[1,2,4]triazol-3-ylmethyl)-piperidine | CHEMBL99792 |
Type | Small organic molecule |
Emp. Form. | C23H22F6N4O |
Mol. Mass. | 484.4374 |
SMILES | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnc[nH]3)[C@H]2c2ccccc2)cc(c1)C(F)(F)F |
Structure |
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