| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM280408 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1807450 (CHEMBL4306809) |
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| EC50 | 11±n/a nM |
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| Citation |  Yang, Q; Lachapelle, EA; Kablaoui, NM; Webb, D; Popiolek, M; Grimwood, S; Kozak, R; O'Connor, RE; Lazzaro, JT; Butler, CR; Zhang, L Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres. ACS Med Chem Lett10:941-948 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 53079.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
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| Residue: | 479 |
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| Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM280408 |
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| n/a |
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| Name | BDBM280408 |
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| Synonyms: | US10030012, Example 38 | ethyl 4-[4-(3- methoxypyridin- 2-yl)piperidin-1- yl]azepane-1- carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C20H31N3O3 |
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| Mol. Mass. | 361.4784 |
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| SMILES | CCOC(=O)N1CCCC(CC1)N1CCC(CC1)c1ncccc1OC |
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| Structure | 
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