| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Substance-K receptor |
|---|
| Ligand | BDBM50052515 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_209225 (CHEMBL814853) |
|---|
| EC50 | >50000±n/a nM |
|---|
| Citation |  Byk, G; Halle, D; Zeltser, I; Bitan, G; Selinger, Z; Gilon, C Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. J Med Chem39:3174-8 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Substance-K receptor |
|---|
| Name: | Substance-K receptor |
|---|
| Synonyms: | NK-2 receptor | NK-2R | NK2R_RAT | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | SKR | Substance-K receptor | Tac2r | Tachykinin receptor 2 | Tacr2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43868.63 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Neurokinin NK2 TACR2 Murine::P16610 |
|---|
| Residue: | 390 |
|---|
| Sequence: | MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILA
HERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATK
CVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLR
HLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMT
GDMTHSEATNGQVGSPQDGEPAGPICKAQA
|
|
|
|---|
| BDBM50052515 |
|---|
| n/a |
|---|
| Name | BDBM50052515 |
|---|
| Synonyms: | (S)-2-{2-[(2S,5R,8S)-5,8-Dibenzyl-2-(3-guanidino-propyl)-3,6,9,15,19-pentaoxo-1,4,7,10,14pentaaza-cyclononadec-10-yl]-acetylamino}-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide | CHEMBL264395 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C45H67N11O8S |
|---|
| Mol. Mass. | 922.147 |
|---|
| SMILES | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
