| Reaction Details |
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 | Report a problem with these data |
| Target | Target of rapamycin complex 2 subunit MAPKAP1 |
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| Ligand | BDBM50348452 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1809504 (CHEMBL4308964) |
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| IC50 | 2.8±n/a nM |
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| Citation |  He, S; Li, Q; Jiang, X; Lu, X; Feng, F; Qu, W; Chen, Y; Sun, H Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy. J Med Chem61:4656-4687 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Target of rapamycin complex 2 subunit MAPKAP1 |
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| Name: | Target of rapamycin complex 2 subunit MAPKAP1 |
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| Synonyms: | MAPKAP1 | MIP1 | Mitogen-activated protein kinase 2-associated protein 1 | SAPK-interacting protein 1 | SIN1 | SIN1_HUMAN | Stress-activated map kinase-interacting protein 1 | TORC2 subunit MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | mSIN1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59129.70 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119716 |
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| Residue: | 522 |
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| Sequence: | MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT
MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD
GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS
TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL
KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
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| BDBM50348452 |
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| n/a |
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| Name | BDBM50348452 |
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| Synonyms: | AZD-8055 | CHEMBL1801204 | US9102670, 1a |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N5O4 |
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| Mol. Mass. | 465.5447 |
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| SMILES | COc1ccc(cc1CO)-c1ccc2c(nc(nc2n1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C |r| |
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| Structure | 
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