| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1 |
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| Ligand | BDBM50054239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_51123 (CHEMBL663558) |
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| Ki | 1050±n/a nM |
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| Citation |  Whitten, JP; Xie, YF; Erickson, PE; Webb, TR; De Souza, EB; Grigoriadis, DE; McCarthy, JR Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: application to the synthesis and optimization of corticotropin-releasing factor1 receptor antagonists. J Med Chem39:4354-7 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 1 |
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| Name: | Corticotropin-releasing factor receptor 1 |
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| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 50744.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34998 |
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| Residue: | 444 |
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| Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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| BDBM50054239 |
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| n/a |
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| Name | BDBM50054239 |
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| Synonyms: | CHEMBL78035 | [4-(3,6-Dihydro-2H-pyridin-1-yl)-6-methyl-[1,3,5]triazin-2-yl]-(2,4,6-trimethyl-phenyl)-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23N5 |
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| Mol. Mass. | 309.4087 |
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| SMILES | Cc1cc(C)c(Nc2nc(C)nc(n2)N2CCC=CC2)c(C)c1 |c:18| |
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| Structure | 
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