| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50503649 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1811382 (CHEMBL4310842) |
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| Ki | 200000±n/a nM |
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| Citation |  Chowdhury, SR; Kennedy, S; Zhu, K; Mishra, R; Chuong, P; Nguyen, AU; Kathman, SG; Statsyuk, AV Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments. Bioorg Med Chem Lett29:36-39 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM50503649 |
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| n/a |
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| Name | BDBM50503649 |
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| Synonyms: | CHEMBL4476113 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29ClN4O3 |
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| Mol. Mass. | 432.944 |
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| SMILES | CC1(CC1)c1cc(NCC(=O)N2CCN(CC2)C2CN(C2)C(=O)C=C)c(O)cc1Cl |
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| Structure | 
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