| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-2 catalytic subunit |
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| Ligand | BDBM50503847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1812367 (CHEMBL4311827) |
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| IC50 | 34±n/a nM |
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| Citation |  Pehere, AD; Nguyen, S; Garlick, SK; Wilson, DW; Hudson, I; Sykes, MJ; Morton, JD; Abell, AD Tripeptide analogues of MG132 as protease inhibitors. Bioorg Med Chem27:436-441 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-2 catalytic subunit |
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| Name: | Calpain-2 catalytic subunit |
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| Synonyms: | 3.4.22.53 | CAN2_PIG | CANP 2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain-2 catalytic subunit | Calpain-2 large subunit | M-calpain | Millimolar-calpain |
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| Type: | n/a |
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| Mol. Mass.: | 37789.71 |
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| Organism: | Sus scrofa |
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| Description: | n/a |
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| Residue: | 324 |
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| Sequence: | YPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEV
PEELTGQTNIHLSKNFFLTHRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD
FCIRVFSEKKADYQVVDDEIEADLEENDASEDDIDDGFRRLFAQLAGEDAEISAFELQTI
LRRVLAKRQDIKSDGFSIETCRIMVDMLDSDGSAKLGLKEFYILWTKIQKYQKIYREIDV
DRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFRIS
KQLDSENTGTIELDLISWLCFSVL
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| BDBM50503847 |
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| n/a |
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| Name | BDBM50503847 |
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| Synonyms: | CHEMBL4574306 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H39N3O6 |
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| Mol. Mass. | 597.7007 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(OCC#C)cc1)C=O |r| |
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| Structure | 
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