Reaction Details |
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Target | Acidic mammalian chitinase |
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Ligand | BDBM50504037 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1813251 (CHEMBL4312825) |
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IC50 | 21±n/a nM |
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Citation | Mazur, M; Dymek, B; Koralewski, R; Sklepkiewicz, P; Olejniczak, S; Mazurkiewicz, M; Piotrowicz, M; Salamon, M; J?drzejczak, K; Zagozdzon, A; Czestkowski, W; Matyszewski, K; Borek, B; Bartoszewicz, A; Pluta, E; Rymaszewska, A; Mozga, W; Stefaniak, F; Dobrza?ski, P; Dzwonek, K; Golab, J; Golebiowski, A; Olczak, J Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases. J Med Chem62:7126-7145 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acidic mammalian chitinase |
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Name: | Acidic mammalian chitinase |
Synonyms: | AMCase | CHIA_MOUSE | Chia | Chia1 | YNL |
Type: | PROTEIN |
Mol. Mass.: | 51991.60 |
Organism: | Mus musculus |
Description: | ChEMBL_828636 |
Residue: | 473 |
Sequence: | MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAG
MQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFI
TSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMV
TAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAY
LNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGF
WAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIW
AIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGS
SGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
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BDBM50504037 |
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n/a |
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Name | BDBM50504037 |
Synonyms: | CHEMBL4470253 |
Type | Small organic molecule |
Emp. Form. | C19H27ClN6O |
Mol. Mass. | 390.91 |
SMILES | CO[C@@H]1C[C@H](Cc2ccc(Cl)cc2)N(C1)C1CCN(CC1)c1nc(N)n[nH]1 |r| |
Structure |
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