| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acidic mammalian chitinase |
|---|
| Ligand | BDBM50504014 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1813253 (CHEMBL4312827) |
|---|
| IC50 | 50±n/a nM |
|---|
| Citation |  Mazur, M; Dymek, B; Koralewski, R; Sklepkiewicz, P; Olejniczak, S; Mazurkiewicz, M; Piotrowicz, M; Salamon, M; J?drzejczak, K; Zagozdzon, A; Czestkowski, W; Matyszewski, K; Borek, B; Bartoszewicz, A; Pluta, E; Rymaszewska, A; Mozga, W; Stefaniak, F; Dobrza?ski, P; Dzwonek, K; Golab, J; Golebiowski, A; Olczak, J Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases. J Med Chem62:7126-7145 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acidic mammalian chitinase |
|---|
| Name: | Acidic mammalian chitinase |
|---|
| Synonyms: | AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 52266.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BZP6 |
|---|
| Residue: | 476 |
|---|
| Sequence: | MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
|
|
|
|---|
| BDBM50504014 |
|---|
| n/a |
|---|
| Name | BDBM50504014 |
|---|
| Synonyms: | CHEMBL4547227 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H25ClN6O |
|---|
| Mol. Mass. | 376.884 |
|---|
| SMILES | Nc1n[nH]c(n1)N1CCC(CC1)N1C[C@H](O)C[C@@H]1Cc1ccc(Cl)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
