Ki Summary

Reaction Details

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Target

Gamma-aminobutyric acid receptor subunit gamma-1

Ligand

BDBM50055953

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_193817 (CHEMBL872982)

IC50

5100±n/a nM

Citation

Upasani, RB; Yang, KC; Acosta-Burruel, M; Konkoy, CS; McLellan, JA; Woodward, RM; Lan, NC; Carter, RB; Hawkinson, JE 3 alpha-Hydroxy-3 beta-(phenylethynyl)-5 beta-pregnan-20-ones: synthesis and pharmacological activity of neuroactive steroids with high affinity for GABAA receptors. J Med Chem40:73-84 (1997) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gamma-aminobutyric acid receptor subunit gamma-1

Name:

Gamma-aminobutyric acid receptor subunit gamma-1

Synonyms:

Benzodiazepine receptors | Benzodiazepine receptors; peripheral & central | GABA receptor gamma-1 subunit | GBRG1_RAT | Gabrg1

Type:

PROTEIN

Mol. Mass.:

53557.84

Organism:

Rattus norvegicus

Description:

ChEMBL_193817

Residue:

465

Sequence:

MGSGKVFLFSPSLLWSQTRGVRLIFLLLTLHLGNCIDKADDEDDEDLTMNKTWVLAPKIH
EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF
DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTL
RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF
VGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP
ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN
NKGKTTRDRKLKSKTSVSPGLHAGSTLIPMNNISMPQGEDDYGYQCLEGKDCATFFCCFE
DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL

BDBM50055953

n/a

Name

BDBM50055953

Synonyms:

1-[(3R,5R,10S,13S,17S)-3-Hydroxy-3-(2-hydroxy-phenylethynyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-ethanone | CHEMBL3138017

Type

Small organic molecule

Emp. Form.

C29H38O3

Mol. Mass.

434.6102

SMILES

[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@](O)(CC[C@]12C)C#Cc1ccccc1O

Structure