Reaction Details |
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Target | Serine/threonine-protein kinase pim-2 |
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Ligand | BDBM50005209 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1817340 (CHEMBL4317000) |
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Ki | 0.200000±n/a nM |
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Citation | Wang, X; Blackaby, W; Allen, V; Chan, GKY; Chang, JH; Chiang, PC; Dične, C; Drummond, J; Do, S; Fan, E; Harstad, EB; Hodges, A; Hu, H; Jia, W; Kofie, W; Kolesnikov, A; Lyssikatos, JP; Ly, J; Matteucci, M; Moffat, JG; Munugalavadla, V; Murray, J; Nash, D; Noland, CL; Del Rosario, G; Ross, L; Rouse, C; Sharpe, A; Slaga, D; Sun, M; Tsui, V; Wallweber, H; Yu, SF; Ebens, AJ Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma. J Med Chem62:2140-2153 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase pim-2 |
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Name: | Serine/threonine-protein kinase pim-2 |
Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 34185.93 |
Organism: | Homo sapiens (Human) |
Description: | Q9P1W9 |
Residue: | 311 |
Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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BDBM50005209 |
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n/a |
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Name | BDBM50005209 |
Synonyms: | CHEMBL3103867 |
Type | Small organic molecule |
Emp. Form. | C22H23FN6O |
Mol. Mass. | 406.456 |
SMILES | N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F |r| |
Structure |
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