Reaction Details |
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Target | Neuronal acetylcholine receptor subunit alpha-7 |
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Ligand | BDBM50056147 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_144029 (CHEMBL750444) |
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Ki | >10000±n/a nM |
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Citation | Lin, NH; Gunn, DE; Ryther, KB; Garvey, DS; Donnelly-Roberts, DL; Decker, MW; Brioni, JD; Buckley, MJ; Rodrigues, AD; Marsh, KG; Anderson, DJ; Buccafusco, JJ; Prendergast, MA; Sullivan, JP; Williams, M; Arneric, SP; Holladay, MW Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. J Med Chem40:385-90 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neuronal acetylcholine receptor subunit alpha-7 |
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Name: | Neuronal acetylcholine receptor subunit alpha-7 |
Synonyms: | ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) |
Type: | n/a |
Mol. Mass.: | 56448.33 |
Organism: | Homo sapiens (Human) |
Description: | CHRNA7 (NACHRA7) |
Residue: | 502 |
Sequence: | MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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BDBM50056147 |
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n/a |
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Name | BDBM50056147 |
Synonyms: | 2-Methyl-3-((S)-1-pyrrolidin-2-ylmethoxy)-pyridine | ABT-089 | CHEMBL127071 |
Type | Small organic molecule |
Emp. Form. | C11H16N2O |
Mol. Mass. | 192.2575 |
SMILES | Cc1ncccc1OC[C@@H]1CCCN1 |
Structure |
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