| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50057316 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_52850 (CHEMBL664374) |
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| IC50 | >12000±n/a nM |
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| Citation |  Gangjee, A; Mavandadi, F; Queener, SF Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. J Med Chem40:1173-7 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23891.29 |
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| Organism: | Pneumocystis carinii |
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| Description: | n/a |
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| Residue: | 206 |
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| Sequence: | MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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| BDBM50057316 |
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| n/a |
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| Name | BDBM50057316 |
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| Synonyms: | 5-(((2,5-dimethoxyphenyl)(methyl)amino)methyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | 5-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | CHEMBL17453 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20N6O2 |
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| Mol. Mass. | 328.369 |
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| SMILES | COc1ccc(OC)c(c1)N(C)Cc1c[nH]c2nc(N)nc(N)c12 |
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| Structure | 
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