Reaction Details |
| Report a problem with these data |
Target | Dihydrofolate reductase |
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Ligand | BDBM50057318 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_52850 (CHEMBL664374) |
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IC50 | 929000.0±n/a nM |
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Citation | Gangjee, A; Mavandadi, F; Queener, SF Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. J Med Chem40:1173-7 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 23891.29 |
Organism: | Pneumocystis carinii |
Description: | n/a |
Residue: | 206 |
Sequence: | MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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BDBM50057318 |
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n/a |
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Name | BDBM50057318 |
Synonyms: | 5-(Naphthalen-2-ylsulfanylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | CHEMBL275893 |
Type | Small organic molecule |
Emp. Form. | C17H15N5S |
Mol. Mass. | 321.4 |
SMILES | Nc1nc(N)c2c(CSc3ccc4ccccc4c3)c[nH]c2n1 |
Structure |
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