| Reaction Details |
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 | Report a problem with these data |
| Target | Lysyl oxidase homolog 2 |
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| Ligand | BDBM50232678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1823505 (CHEMBL4323269) |
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| IC50 | 398±n/a nM |
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| Citation |  Findlay, AD; Foot, JS; Buson, A; Deodhar, M; Jarnicki, AG; Hansbro, PM; Liu, G; Schilter, H; Turner, CI; Zhou, W; Jarolimek, W Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3. J Med Chem62:9874-9889 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysyl oxidase homolog 2 |
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| Name: | Lysyl oxidase homolog 2 |
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| Synonyms: | 1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86721.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_115990 |
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| Residue: | 774 |
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| Sequence: | MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRL
AGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGP
IWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLN
IQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGER
TYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVS
CVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSA
SVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDA
GVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQL
GLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAG
VACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFS
SQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLED
TECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEV
AESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
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| BDBM50232678 |
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| n/a |
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| Name | BDBM50232678 |
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| Synonyms: | CHEBI:27413 | CHEMBL1618272 | US10717734, Compound BAPN | US11098045, Compound BAPN |
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| Type | Small organic molecule |
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| Emp. Form. | C3H6N2 |
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| Mol. Mass. | 70.0931 |
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| SMILES | NCCC#N |
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| Structure | 
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