| Reaction Details |
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 | Report a problem with these data |
| Target | Stimulator of interferon genes protein |
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| Ligand | BDBM50506263 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1825361 (CHEMBL4325125) |
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| IC50 | 5.5±n/a nM |
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| Citation |  Xi, Q; Wang, M; Jia, W; Yang, M; Hu, J; Jin, J; Chen, X; Yin, D; Wang, X Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists. J Med Chem63:260-282 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stimulator of interferon genes protein |
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| Name: | Stimulator of interferon genes protein |
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| Synonyms: | ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING |
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| Type: | Protein |
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| Mol. Mass.: | 42195.64 |
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| Organism: | Human |
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| Description: | Q86WV6 |
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| Residue: | 379 |
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| Sequence: | MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLL
NGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWM
LALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIR
TYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVY
SNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILA
DAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQE
PELLISGMEKPLPLRTDFS
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| BDBM50506263 |
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| n/a |
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| Name | BDBM50506263 |
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| Synonyms: | CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N10O13P2 |
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| Mol. Mass. | 674.4113 |
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| SMILES | [H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc3c1nc(N)[nH]c3=O)[C@@H]2O)n1cnc2c(N)ncnc12 |r| |
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| Structure | 
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