| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM8133 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1825412 (CHEMBL4325176) |
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| IC50 | 158±n/a nM |
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| Citation |  Tear, WF; Bag, S; Diaz-Gonzalez, R; Ceballos-Pérez, G; Rojas-Barros, DI; Cordon-Obras, C; Pérez-Moreno, G; García-Hernández, R; Martinez-Martinez, MS; Ruiz-Perez, LM; Gamarro, F; Gonzalez Pacanowska, D; Caffrey, CR; Ferrins, L; Manzano, P; Navarro, M; Pollastri, MP Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5- J Med Chem63:756-783 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM8133 |
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| n/a |
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| Name | BDBM8133 |
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| Synonyms: | N-(4-tert-butylphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine | pyrazolo[1,5-b]pyridazine deriv. 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N6 |
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| Mol. Mass. | 344.413 |
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| SMILES | CC(C)(C)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1 |
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| Structure | 
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