Reaction Details |
| Report a problem with these data |
Target | Neutrophil elastase |
---|
Ligand | BDBM50058477 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_63796 (CHEMBL679049) |
---|
IC50 | 38±n/a nM |
---|
Citation | Portevin, B; Lonchampt, M; Canet, E; De Nanteuil, G Dual inhibition of human leukocyte elastase and lipid peroxidation: in vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives. J Med Chem40:1906-18 (1997) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neutrophil elastase |
---|
Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
|
|
|
BDBM50058477 |
---|
n/a |
---|
Name | BDBM50058477 |
Synonyms: | (2R,3aR,7aR)-1-(2-{4-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-acetylsulfamoyl]-benzoylamino}-3-methyl-butyryl)-octahydro-indole-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide | CHEMBL56685 |
Type | Small organic molecule |
Emp. Form. | C43H59F3N4O8S |
Mol. Mass. | 849.011 |
SMILES | CC(C)C(NC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)C(=O)N1[C@H](C[C@H]2CCCC[C@@H]12)C(=O)NC(C(C)C)C(=O)C(F)(F)F |
Structure |
|