| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50058495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63796 (CHEMBL679049) |
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| IC50 | 0.1±n/a nM |
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| Citation |  Portevin, B; Lonchampt, M; Canet, E; De Nanteuil, G Dual inhibition of human leukocyte elastase and lipid peroxidation: in vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives. J Med Chem40:1906-18 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50058495 |
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| n/a |
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| Name | BDBM50058495 |
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| Synonyms: | 3-{2-[2-(Thiophene-2-carbonylsulfanyl)-propionylamino]-acetyl}-thiazolidine-4-carboxylic acid | CHEMBL293138 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N2O5S3 |
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| Mol. Mass. | 388.482 |
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| SMILES | CC(SC(=O)c1cccs1)C(=O)NCC(=O)N1CSCC1C(O)=O |
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| Structure | 
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