| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Ligand | BDBM50059054 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_155185 (CHEMBL761832) |
|---|
| IC50 | 11±n/a nM |
|---|
| Citation |  Ahn, HS; Bercovici, A; Boykow, G; Bronnenkant, A; Chackalamannil, S; Chow, J; Cleven, R; Cook, J; Czarniecki, M; Domalski, C; Fawzi, A; Green, M; Gündes, A; Ho, G; Laudicina, M; Lindo, N; Ma, K; Manna, M; McKittrick, B; Mirzai, B; Nechuta, T; Neustadt, B; Puchalski, C; Pula, K; Zhang, H Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity. J Med Chem40:2196-210 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Synonyms: | PDE5 | PDE5A | PDE5A_BOVIN | Phosphodiesterase 5A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 98615.45 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_155186 |
|---|
| Residue: | 865 |
|---|
| Sequence: | MERAGPGSARPQQQWDQDSVEAWLDDHWDFTFSYFVRKGTREMVNAWFAERVHTIPVCKE
GIKGHTESCSCPLQPSPRAESSVPGTPTRKISASEFDRPLRPIVIKDSEGTVSFLSDSDK
KEQMPLTSPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV
CEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR
FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC
GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF
IVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKD
KRFPWTNENMGNINQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKAFNRNDEQ
FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPS
AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCKWILSVKKNYRKNV
AYHNWRHAFNTAQCMFAALKAGKIQKRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEH
PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIK
RRGEFFELIMKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQG
DRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNR
QKWQALAEQQEKTLINGESSQTKRN
|
|
|
|---|
| BDBM50059054 |
|---|
| n/a |
|---|
| Name | BDBM50059054 |
|---|
| Synonyms: | 5'-Methyl-2'-phenyl-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4(5'H)-one | CHEMBL304161 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H25N5O |
|---|
| Mol. Mass. | 411.4989 |
|---|
| SMILES | CN1C2=NC3(CCCC3)CN2c2nc(-c3ccccc3)n(Cc3ccccc3)c2C1=O |t:2| |
|---|
| Structure | 
|
|---|
Search and Browse
