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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Polymerase basic protein 2 | ||
| Ligand | BDBM50507222 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1829449 (CHEMBL4329323) | ||
| EC50 | 9.6±n/a nM | ||
| Citation |  Xiong, J; Wang, J; Hu, G; Zhao, W; Li, J Design, synthesis and biological evaluation of novel, orally bioavailable pyrimidine-fused heterocycles as influenza PB2 inhibitors. Eur J Med Chem162:249-265 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Polymerase basic protein 2 | |||
| Name: | Polymerase basic protein 2 | ||
| Synonyms: | PB2 | PB2_I34A1 | Polymerase basic protein 2 | RNA-directed RNA polymerase subunit P3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 86120.80 | ||
| Organism: | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) | ||
| Description: | ChEMBL_109460 | ||
| Residue: | 759 | ||
| Sequence: |
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| BDBM50507222 | |||
| n/a | |||
| Name | BDBM50507222 | ||
| Synonyms: | CHEMBL4459959 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H22F2N6O2 | ||
| Mol. Mass. | 452.4566 | ||
| SMILES | Cn1cc(F)c2c(N[C@H]3C4CCC(CC4)[C@@H]3C(O)=O)nc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:15.17,wD:8.7,(19.15,-35.75,;20.47,-34.99,;20.63,-33.46,;22.14,-33.14,;22.76,-31.74,;22.91,-34.47,;24.41,-34.78,;25.72,-34,;27.05,-34.75,;27.06,-36.31,;28.39,-37.06,;29.73,-36.29,;29.72,-34.74,;28.94,-35.92,;27.82,-35.01,;28.37,-33.97,;28.36,-32.43,;27.02,-31.67,;29.69,-31.65,;24.88,-36.23,;23.86,-37.37,;22.36,-37.07,;21.88,-35.62,;24.35,-38.82,;23.45,-40.08,;24.36,-41.33,;25.82,-40.84,;27.16,-41.61,;28.5,-40.84,;28.49,-39.29,;29.83,-38.51,;27.16,-38.52,;25.82,-39.3,)| | ||
| Structure | 
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