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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Polymerase basic protein 2 | ||
| Ligand | BDBM50507224 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1829449 (CHEMBL4329323) | ||
| EC50 | 70±n/a nM | ||
| Citation |  Xiong, J; Wang, J; Hu, G; Zhao, W; Li, J Design, synthesis and biological evaluation of novel, orally bioavailable pyrimidine-fused heterocycles as influenza PB2 inhibitors. Eur J Med Chem162:249-265 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Polymerase basic protein 2 | |||
| Name: | Polymerase basic protein 2 | ||
| Synonyms: | PB2 | PB2_I34A1 | Polymerase basic protein 2 | RNA-directed RNA polymerase subunit P3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 86120.80 | ||
| Organism: | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) | ||
| Description: | ChEMBL_109460 | ||
| Residue: | 759 | ||
| Sequence: |
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| BDBM50507224 | |||
| n/a | |||
| Name | BDBM50507224 | ||
| Synonyms: | CHEMBL4580408 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H19FN6O2 | ||
| Mol. Mass. | 430.4344 | ||
| SMILES | OC(=O)[C@H]1C2CCC(CC2)[C@@H]1n1cc(C#N)c2cnc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(29.83,-2.09,;31.16,-2.85,;32.49,-2.07,;31.17,-4.39,;32.52,-5.15,;32.53,-6.69,;31.2,-7.47,;29.87,-6.71,;30.63,-5.42,;31.74,-6.33,;29.86,-5.17,;28.55,-4.41,;27.51,-3.27,;26.11,-3.91,;24.79,-3.15,;23.47,-2.4,;26.28,-5.44,;25.26,-6.59,;25.74,-8.05,;27.24,-8.37,;28.27,-7.21,;27.79,-5.75,;27.72,-9.82,;26.82,-11.07,;27.73,-12.31,;29.19,-11.83,;30.53,-12.6,;31.86,-11.83,;31.86,-10.28,;33.19,-9.5,;30.53,-9.51,;29.19,-10.29,)| | ||
| Structure | 
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