| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-hexosaminidase subunit beta |
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| Ligand | BDBM50507471 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1830123 (CHEMBL4329997) |
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| Ki | 5100±n/a nM |
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| Citation |  Shen, S; Dong, L; Chen, W; Zeng, X; Lu, H; Yang, Q; Zhang, J Modification of the Thioglycosyl-Naphthalimides as Potent and Selective Human O-GlcNAcase Inhibitors. ACS Med Chem Lett9:1241-1246 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-hexosaminidase subunit beta |
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| Name: | Beta-hexosaminidase subunit beta |
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| Synonyms: | Beta-N-acetylhexosaminidase subunit beta | Beta-hexosaminidase subunit beta | Beta-hexosaminidase subunit beta (Hex B) | HEXB | HEXB_HUMAN | Hexosaminidase subunit B |
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| Type: | Enzyme |
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| Mol. Mass.: | 63112.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07686 |
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| Residue: | 556 |
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| Sequence: | MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLP
LLVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQA
KTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY
QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVD
DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGK
GQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKC
WESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI
VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQL
FIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG
IAAQPLYAGYCNHENM
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| BDBM50507471 |
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| n/a |
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| Name | BDBM50507471 |
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| Synonyms: | CHEMBL4540913 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30BrN3O7S |
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| Mol. Mass. | 596.491 |
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| SMILES | CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1SCCCNCCN1C(=O)c2cccc3c(Br)ccc(C1=O)c23 |r| |
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| Structure | 
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