| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutrophil elastase |
|---|
| Ligand | BDBM50060329 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_63999 (CHEMBL673108) |
|---|
| Ki | 1300±n/a nM |
|---|
| Citation |  Regan, J; McGarry, D; Bruno, J; Green, D; Newman, J; Hsu, CY; Kline, J; Barton, J; Travis, J; Choi, YM; Volz, F; Pauls, H; Harrison, R; Zilberstein, A; Ben-Sasson, SA; Chang, M Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase. J Med Chem40:3408-22 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutrophil elastase |
|---|
| Name: | Neutrophil elastase |
|---|
| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28532.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08246 |
|---|
| Residue: | 267 |
|---|
| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
|
|
|
|---|
| BDBM50060329 |
|---|
| n/a |
|---|
| Name | BDBM50060329 |
|---|
| Synonyms: | CHEMBL385442 | {2-{4-[5-Carboxymethoxy-4-(5-hydroxy-2-methoxy-4-methyl-benzyl)-2-methoxy-benzyl]-5-hydroxy-2-methoxy-benzyl}-5-[4-(2-carboxymethoxy-5-methoxy-benzyl)-2-hydroxy-5-methoxy-benzyl]-4-methoxy-phenoxy}-acetic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C54H56O18 |
|---|
| Mol. Mass. | 993.0116 |
|---|
| SMILES | COc1ccc(OCC(O)=O)c(Cc2cc(O)c(Cc3cc(OCC(O)=O)c(Cc4cc(O)c(Cc5cc(OCC(O)=O)c(Cc6cc(O)c(C)cc6OC)cc5OC)cc4OC)cc3OC)cc2OC)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
