| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50060331 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63999 (CHEMBL673108) |
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| Ki | 1300±n/a nM |
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| Citation |  Regan, J; McGarry, D; Bruno, J; Green, D; Newman, J; Hsu, CY; Kline, J; Barton, J; Travis, J; Choi, YM; Volz, F; Pauls, H; Harrison, R; Zilberstein, A; Ben-Sasson, SA; Chang, M Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase. J Med Chem40:3408-22 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50060331 |
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| n/a |
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| Name | BDBM50060331 |
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| Synonyms: | CHEMBL412744 | bis-[4-tert-Butyl-2-[5-tert-butyl-3-(5-tert-butyl-2-carboxymethoxy-benzyl)-2-carboxymethoxy-benzyl]-6-(5-tert-butyl-2-carboxymethoxy-benzyl)-phenoxy]-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C104H128O24 |
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| Mol. Mass. | 1762.1147 |
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| SMILES | CC(C)(C)c1cc2Cc3cc(cc(Cc4cc(cc(Cc5cc(cc(Cc6cc(cc(Cc7cc(cc(Cc8cc(cc(Cc9cc(cc(Cc(c1)c2OCC(O)=O)c9OCC(O)=O)C(C)(C)C)c8OCC(O)=O)C(C)(C)C)c7OCC(O)=O)C(C)(C)C)c6OCC(O)=O)C(C)(C)C)c5OCC(O)=O)C(C)(C)C)c4OCC(O)=O)C(C)(C)C)c3OCC(O)=O)C(C)(C)C |
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| Structure | 
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