| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50060333 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63661 (CHEMBL675717) |
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| IC50 | 3360000±n/a nM |
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| Citation |  Buynak, JD; Rao, AS; Ford, GP; Carver, C; Adam, G; Geng, B; Bachmann, B; Shobassy, S; Lackey, S 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase. J Med Chem40:3423-33 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50060333 |
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| n/a |
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| Name | BDBM50060333 |
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| Synonyms: | 3-Acetoxymethyl-7-[1-bromo-meth-(E)-ylidene]-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester | CHEMBL116840 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20BrNO7S |
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| Mol. Mass. | 546.387 |
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| SMILES | CC(=O)OCC1=C(N2C(\C(=C\Br)C2=O)S(=O)(=O)C1)C(=O)OC(c1ccccc1)c1ccccc1 |t:5| |
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| Structure | 
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