| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50000317 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_207780 (CHEMBL880940) |
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| IC50 | 28±n/a nM |
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| Citation |  Dickinson, RP; Dack, KN; Long, CJ; Steele, J Thromboxane modulating agents. 3. 1H-imidazol-1-ylalkyl- and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists. J Med Chem40:3442-52 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 60524.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24557 |
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| Residue: | 533 |
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| Sequence: | MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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| BDBM50000317 |
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| n/a |
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| Name | BDBM50000317 |
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| Synonyms: | 3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-propionic acid | 3-(3-Imidazol-1-ylmethyl-indol-1-yl)-propionic acid | CHEMBL283656 | Dazmegrel | UK-38485 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17N3O2 |
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| Mol. Mass. | 283.3251 |
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| SMILES | Cc1c(Cn2ccnc2)c2ccccc2n1CCC(O)=O |
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| Structure | 
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