| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Discoidin domain-containing receptor 2 |
|---|
| Ligand | BDBM50507707 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1831413 (CHEMBL4331421) |
|---|
| IC50 | 2.6±n/a nM |
|---|
| Citation |  Wang, L; Zhang, Y; Zhang, Q; Zhu, G; Zhang, Z; Duan, C; Lu, T; Tang, W Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance. Eur J Med Chem163:243-255 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Discoidin domain-containing receptor 2 |
|---|
| Name: | Discoidin domain-containing receptor 2 |
|---|
| Synonyms: | DDR2 | DDR2_HUMAN | Discoidin domain receptor 2 (DDR2) | Discoidin domain-containing receptor 2 | Discoidin domain-containing receptor 2 (DDR2) | Epithelial discoidin domain-containing receptor 2 (DDR2) | NTRKR3 | TKT | TYRO10 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 96717.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16832 |
|---|
| Residue: | 855 |
|---|
| Sequence: | MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY
GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI
NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV
ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD
DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK
EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS
EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL
WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD
YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV
PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN
QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG
DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK
NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET
FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP
SFQEIHLLLLQQGDE
|
|
|
|---|
| BDBM50507707 |
|---|
| n/a |
|---|
| Name | BDBM50507707 |
|---|
| Synonyms: | CHEMBL4466555 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H18ClF3N6O2 |
|---|
| Mol. Mass. | 514.887 |
|---|
| SMILES | Cc1ccc(cc1NC(=O)C1(CC1)c1ncnc2[nH]cnc12)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
