Reaction Details |
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Target | Serine/threonine-protein kinase A-Raf |
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Ligand | BDBM50096279 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1831489 (CHEMBL4331497) |
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IC50 | 1.2±n/a nM |
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Citation | Wang, L; Zhang, Y; Zhang, Q; Zhu, G; Zhang, Z; Duan, C; Lu, T; Tang, W Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance. Eur J Med Chem163:243-255 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase A-Raf |
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Name: | Serine/threonine-protein kinase A-Raf |
Synonyms: | ARAF | ARAF1 | ARAF_HUMAN | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks | RAF serine/threonine protein kinase |
Type: | Enzyme |
Mol. Mass.: | 67610.81 |
Organism: | Homo sapiens (Human) |
Description: | P10398 |
Residue: | 606 |
Sequence: | MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
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BDBM50096279 |
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n/a |
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Name | BDBM50096279 |
Synonyms: | CHEMBL3577124 |
Type | Small organic molecule |
Emp. Form. | C23H29FN6O |
Mol. Mass. | 424.5144 |
SMILES | CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C |
Structure |
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