| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase A-Raf |
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| Ligand | BDBM50507704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1831489 (CHEMBL4331497) |
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| IC50 | 52±n/a nM |
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| Citation |  Wang, L; Zhang, Y; Zhang, Q; Zhu, G; Zhang, Z; Duan, C; Lu, T; Tang, W Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance. Eur J Med Chem163:243-255 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase A-Raf |
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| Name: | Serine/threonine-protein kinase A-Raf |
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| Synonyms: | ARAF | ARAF1 | ARAF_HUMAN | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks | RAF serine/threonine protein kinase |
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| Type: | Enzyme |
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| Mol. Mass.: | 67610.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10398 |
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| Residue: | 606 |
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| Sequence: | MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
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| BDBM50507704 |
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| n/a |
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| Name | BDBM50507704 |
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| Synonyms: | CHEMBL4586402 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H31F3N6O3 |
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| Mol. Mass. | 592.6114 |
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| SMILES | CN1CCC(CC1)Oc1ccc(NC(=O)c2ccc(C)c(NC(=O)C3(CC3)c3ncnc4[nH]ccc34)c2)cc1C(F)(F)F |
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| Structure | 
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