| Reaction Details |
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 | Report a problem with these data |
| Target | Type 1 fimbrin D-mannose specific adhesin |
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| Ligand | BDBM50507943 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1831845 (CHEMBL4331853) |
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| IC50 | 280±n/a nM |
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| Citation |  Maddirala, AR; Klein, R; Pinkner, JS; Kalas, V; Hultgren, SJ; Janetka, JW Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design. J Med Chem62:467-479 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type 1 fimbrin D-mannose specific adhesin |
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| Name: | Type 1 fimbrin D-mannose specific adhesin |
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| Synonyms: | Adhesin protein fimH | FIMH_ECOLI | fimH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31474.61 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | ChEMBL_1298296 |
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| Residue: | 300 |
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| Sequence: | MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLS
TQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRT
DKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTG
GCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQ
GVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ
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| BDBM50507943 |
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| n/a |
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| Name | BDBM50507943 |
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| Synonyms: | CHEMBL4546828 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19NO10 |
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| Mol. Mass. | 421.3549 |
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| SMILES | OC[C@H]1O[C@@H](Oc2ccccc2-c2cc(cc(c2)[N+]([O-])=O)C(O)=O)[C@H](O)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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