| Reaction Details |
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 | Report a problem with these data |
| Target | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Ligand | BDBM50508538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1833217 (CHEMBL4333225) |
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| IC50 | 38±n/a nM |
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| Citation |  Boutard, N; Bia?as, A; Sabiniarz, A; Guzik, P; Banaszak, K; Biela, A; Bie?, M; Buda, A; Bugaj, B; Cieluch, E; Cierpich, A; Dudek, ?; Eggenweiler, HM; Fogt, J; Gaik, M; Gondela, A; Jakubiec, K; Jurzak, M; Kitli?ska, A; Kowalczyk, P; Kujawa, M; Kwieci?ska, K; Le?, M; Lindemann, R; Maciuszek, M; Mikulski, M; Niedziejko, P; Obara, A; Pawlik, H; Rzymski, T; Sieprawska-Lupa, M; Sowi?ska, M; Szeremeta-Spisak, J; Stachowicz, A; Tomczyk, MM; Wiklik, K; W?oszczak, ?; Ziemia?ska, S; Zar?bski, A; Brzózka, K; Nowak, M; Fabritius, CH Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties. Bioorg Med Chem Lett29:646-653 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Synonyms: | 6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) | 6PF-2-K/Fru-2,6-P2ase 3 | 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme | F263_HUMAN | Fructose-2,6-bisphosphatase | PFK/FBPase 3 | PFKFB3 | Renal carcinoma antigen NY-REN-56 | iPFK-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59620.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16875 |
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| Residue: | 520 |
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| Sequence: | MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
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| BDBM50508538 |
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| n/a |
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| Name | BDBM50508538 |
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| Synonyms: | CHEMBL4472403 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H29N7O |
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| Mol. Mass. | 491.5869 |
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| SMILES | CN1CCC(CC1)NC(=O)c1ccncc1Nc1cc(-c2ccc3ccn(C)c3c2)c2nccnc2c1 |
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| Structure | 
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