Reaction Details |
| Report a problem with these data |
Target | Reverse transcriptase/RNaseH |
---|
Ligand | BDBM50032235 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_197283 (CHEMBL804270) |
---|
EC50 | 1.6±n/a nM |
---|
Citation | Kireev, DB; Chrétien, JR; Grierson, DS; Monneret, C A 3D QSAR study of a series of HEPT analogues: the influence of conformational mobility on HIV-1 reverse transcriptase inhibition. J Med Chem40:4257-64 (1998) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Reverse transcriptase/RNaseH |
---|
Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
|
|
|
BDBM50032235 |
---|
n/a |
---|
Name | BDBM50032235 |
Synonyms: | 6-(3,5-Dimethyl-benzyl)-1-ethoxymethyl-5-ethyl-1H-pyrimidine-2,4-dione | 6-(3,5-dimethylbenzyl)-1-ethoxymethyl-5-ethyl-1,2,3,4-tetrahydro-2,4-pyrimidine dione | CHEMBL310976 |
Type | Small organic molecule |
Emp. Form. | C18H24N2O3 |
Mol. Mass. | 316.3948 |
SMILES | CCOCn1c(Cc2cc(C)cc(C)c2)c(CC)c(=O)[nH]c1=O |
Structure |
|