Reaction Details |
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Target | Polymerase acidic protein |
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Ligand | BDBM50508959 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1836507 (CHEMBL4336640) |
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IC50 | 48±n/a nM |
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Citation | Miyagawa, M; Akiyama, T; Taoda, Y; Takaya, K; Takahashi-Kageyama, C; Tomita, K; Yasuo, K; Hattori, K; Shano, S; Yoshida, R; Shishido, T; Yoshinaga, T; Sato, A; Kawai, M Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease. J Med Chem62:8101-8114 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polymerase acidic protein |
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Name: | Polymerase acidic protein |
Synonyms: | Hepatitis C virus polyprotein | PA | PA/PB1 | PA_I34A1 | Polymerase acidic protein | RNA-directed RNA polymerase subunit P2 |
Type: | PROTEIN |
Mol. Mass.: | 82573.84 |
Organism: | Hepatitis C virus |
Description: | ChEMBL_64976 |
Residue: | 716 |
Sequence: | MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGES
IIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQ
EMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNG
YIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNM
KKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDS
SWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKY
CVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSA
ESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
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BDBM50508959 |
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n/a |
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Name | BDBM50508959 |
Synonyms: | CHEMBL4439208 |
Type | Small organic molecule |
Emp. Form. | C25H24N2O6 |
Mol. Mass. | 448.4679 |
SMILES | COCCN1C[C@H](C(c2ccccc2)c2ccccc2)n2cc(C(O)=O)c(=O)c(O)c2C1=O |r| |
Structure |
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