| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase acidic protein |
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| Ligand | BDBM50508961 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1836507 (CHEMBL4336640) |
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| IC50 | 1590±n/a nM |
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| Citation |  Miyagawa, M; Akiyama, T; Taoda, Y; Takaya, K; Takahashi-Kageyama, C; Tomita, K; Yasuo, K; Hattori, K; Shano, S; Yoshida, R; Shishido, T; Yoshinaga, T; Sato, A; Kawai, M Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease. J Med Chem62:8101-8114 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase acidic protein |
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| Name: | Polymerase acidic protein |
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| Synonyms: | Hepatitis C virus polyprotein | PA | PA/PB1 | PA_I34A1 | Polymerase acidic protein | RNA-directed RNA polymerase subunit P2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82573.84 |
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| Organism: | Hepatitis C virus |
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| Description: | ChEMBL_64976 |
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| Residue: | 716 |
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| Sequence: | MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGES
IIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQ
EMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNG
YIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNM
KKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDS
SWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKY
CVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSA
ESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
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| BDBM50508961 |
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| n/a |
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| Name | BDBM50508961 |
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| Synonyms: | CHEMBL4449735 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27N3O5 |
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| Mol. Mass. | 461.5097 |
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| SMILES | CNC(=O)c1cn2[C@H](CN(CCOC)C(=O)c2c(O)c1=O)C(c1ccccc1)c1ccccc1 |r| |
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| Structure | 
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