| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase acidic protein |
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| Ligand | BDBM50509153 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1837761 (CHEMBL4337894) |
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| IC50 | 47.0±n/a nM |
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| Citation |  Credille, CV; Morrison, CN; Stokes, RW; Dick, BL; Feng, Y; Sun, J; Chen, Y; Cohen, SM SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease. J Med Chem62:9438-9449 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase acidic protein |
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| Name: | Polymerase acidic protein |
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| Synonyms: | Hepatitis C virus polyprotein | PA | PA/PB1 | PA_I34A1 | Polymerase acidic protein | RNA-directed RNA polymerase subunit P2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82573.84 |
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| Organism: | Hepatitis C virus |
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| Description: | ChEMBL_64976 |
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| Residue: | 716 |
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| Sequence: | MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGES
IIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQ
EMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNG
YIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNM
KKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDS
SWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKY
CVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSA
ESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
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| BDBM50509153 |
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| n/a |
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| Name | BDBM50509153 |
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| Synonyms: | CHEMBL4551356 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H8F3N5O4 |
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| Mol. Mass. | 367.2396 |
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| SMILES | OC(=O)c1[nH]c(cc(=O)c1O)-c1ccc(cc1C(F)(F)F)-c1nnn[nH]1 |
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| Structure | 
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