| Reaction Details |
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 | Report a problem with these data |
| Target | Catenin beta-1 |
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| Ligand | BDBM50509804 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1839365 (CHEMBL4339580) |
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| Ki | 2600±n/a nM |
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| Citation |  Wang, Z; Zhang, M; Wang, J; Ji, H Optimization of Peptidomimetics as Selective Inhibitors for the ?-Catenin/T-Cell Factor Protein-Protein Interaction. J Med Chem62:3617-3635 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Catenin beta-1 |
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| Name: | Catenin beta-1 |
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| Synonyms: | CTNB1_HUMAN | CTNNB | CTNNB1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85484.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1504364 |
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| Residue: | 781 |
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| Sequence: | MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
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| BDBM50509804 |
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| n/a |
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| Name | BDBM50509804 |
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| Synonyms: | CHEMBL4455488 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H35ClF3N5O9 |
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| Mol. Mass. | 810.172 |
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| SMILES | COc1cc(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc(c1)C(F)(F)F |r| |
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| Structure | 
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