| Reaction Details |
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 | Report a problem with these data |
| Target | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
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| Ligand | BDBM50509993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1839877 (CHEMBL4340092) |
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| IC50 | 65000±n/a nM |
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| Citation |  Coluccia, A; La Regina, G; Naccarato, V; Nalli, M; Orlando, V; Biagioni, S; De Angelis, ML; Baiocchi, M; Gautier, C; Gianni, S; Di Pastena, F; Di Magno, L; Canettieri, G; Coluccia, AML; Silvestri, R Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents. ACS Med Chem Lett10:499-503 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
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| Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
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| Synonyms: | EBP50 | Ezrin-radixin-moesin-binding phosphoprotein 50 | NHERF | NHERF-1 | NHERF1 | NHRF1_HUMAN | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Regulatory cofactor of Na(+)/H(+) exchanger | SLC9A3R1 | Sodium-hydrogen exchanger regulatory factor 1 | Solute carrier family 9 isoform A3 regulatory factor 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38862.94 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118875 |
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| Residue: | 358 |
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| Sequence: | MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLV
EVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQA
EPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIR
SVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFK
KCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQ
DSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL
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| BDBM50509993 |
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| n/a |
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| Name | BDBM50509993 |
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| Synonyms: | CHEMBL4473926 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11ClN2O3 |
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| Mol. Mass. | 314.723 |
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| SMILES | OC(=O)c1ccc(NC(=O)c2c[nH]c3ccc(Cl)cc23)cc1 |
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| Structure | 
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