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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Proto-oncogene tyrosine-protein kinase Src | ||
| Ligand | BDBM3474 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_216860 (CHEMBL816697) | ||
| IC50 | 31±n/a nM | ||
| Citation |  Trumpp-Kallmeyer, S; Rubin, JR; Humblet, C; Hamby, JM; Hollis Showalter, HD Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors. J Med Chem41:1752-63 (1998) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Proto-oncogene tyrosine-protein kinase Src | |||
| Name: | Proto-oncogene tyrosine-protein kinase Src | ||
| Synonyms: | Proto-oncogene c-Src | SRC | SRC_CHICK | Tyrosine-protein kinase SRC | c-Src | p60-Src | p60c-src | pp60c-src | ||
| Type: | Tyr protein kinase | ||
| Mol. Mass.: | 60015.36 | ||
| Organism: | Gallus gallus (Chicken) | ||
| Description: | P00523 | ||
| Residue: | 533 | ||
| Sequence: |
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| BDBM3474 | |||
| n/a | |||
| Name | BDBM3474 | ||
| Synonyms: | 1-cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea | 6-arylpyrido[2,3-d]pyrimidine deriv. 56 | CHEMBL51028 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H36Cl2N8O | ||
| Mol. Mass. | 571.544 | ||
| SMILES | CN1CCN(CCCNc2ncc3cc(c(NC(=O)NC4CCCCC4)nc3n2)-c2c(Cl)cccc2Cl)CC1 |(-14.64,-.8,;-13.31,-.03,;-13.24,1.51,;-11.87,2.22,;-10.57,1.39,;-9.09,1.79,;-8,.7,;-6.51,1.1,;-5.18,.33,;-3.84,1.1,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;2.8,-4.24,;2.74,-5.78,;4.04,-6.6,;5.4,-5.88,;5.46,-4.34,;.16,.33,;-1.17,1.1,;-2.51,.33,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,;-10.64,-.15,;-12.01,-.86,)| | ||
| Structure | 
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