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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Platelet-derived growth factor receptor alpha | ||
| Ligand | BDBM50510924 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1842659 (CHEMBL4343086) | ||
| IC50 | >20000±n/a nM | ||
| Citation |  ?ezní?ková, E; Gucký, T; Ková?ová, V; Ajani, H; Jorda, R; Kry?tof, V Activity of 2,6,9-trisubstituted purines as potent PDGFR? kinase inhibitors with antileukaemic activity. Eur J Med Chem182:0 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Platelet-derived growth factor receptor alpha | |||
| Name: | Platelet-derived growth factor receptor alpha | ||
| Synonyms: | Alpha-type platelet-derived growth factor receptor | PDGFR2 | PDGFRA | PDGFRalpha | PGFRA_HUMAN | Platelet-derived growth factor receptor alpha (PDGFR-alpha) | Platelet-derived growth factor receptor alpha (PDGFRA) | Platelet-derived growth factor receptor, alpha polypeptid | RHEPDGFRA | ||
| Type: | Protein | ||
| Mol. Mass.: | 122633.38 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P16234 | ||
| Residue: | 1089 | ||
| Sequence: |
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| BDBM50510924 | |||
| n/a | |||
| Name | BDBM50510924 | ||
| Synonyms: | CHEMBL4555892 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H36N8O2 | ||
| Mol. Mass. | 480.6057 | ||
| SMILES | N[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccccc2CN2CCOCC2)c2ncn(CCCO)c2n1 |r,wU:1.0,wD:4.7,(19.5,-43.84,;20.83,-44.62,;22.16,-43.86,;23.49,-44.63,;23.48,-46.17,;22.15,-46.94,;20.82,-46.16,;24.81,-46.93,;26.15,-46.17,;26.15,-44.63,;27.47,-43.85,;27.47,-42.32,;28.8,-41.55,;30.13,-42.31,;31.46,-41.54,;31.45,-40,;30.11,-39.24,;28.78,-40.02,;27.45,-39.25,;27.43,-37.71,;28.77,-36.95,;28.76,-35.42,;27.42,-34.65,;26.1,-35.43,;26.1,-36.97,;28.8,-44.62,;30.27,-44.14,;31.18,-45.39,;30.27,-46.64,;30.26,-48.17,;31.58,-48.95,;32.92,-48.19,;34.25,-48.98,;28.81,-46.16,;27.47,-46.94,)| | ||
| Structure | 
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